The best pet calming supplements depend on your pet’s species, the situation that causes stress, and the format they will actually take. I’d put VetriScience Calm & Confident first for its dog-and-cat positioning, choose Purina Pro Plan Calming Care for owners who prefer a daily powder routine, and look at Rescue Remedy drops for a liquid format. The tradeoffs are clear: chews can be easy to offer but may not suit picky eaters, powders require a consistent feeding routine, and drops offer flexibility but need careful administration. Formulas and suggested use differ, so match the label to your pet rather than choosing by ingredient buzzwords alone. Read on for my full comparison and a guide to choosing the right format and routine.
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Key Takeaways
- Format separates the shortlist: most options are chews, while Purina Pro Plan Calming Care uses a powder and Rescue Remedy and Charlie & Buddy offer liquid formats.
- VetriScience and Pet Naturals are labeled for dogs and cats; most other products in this lineup are presented primarily for dogs, so species fit deserves a label check.
- Pack size alone does not establish value: count, serving directions, and how often your pet needs support all affect how practical a supply will be.
- Ingredient combinations vary widely: several chews combine hemp with melatonin or herbs, while Pet Honesty highlights ashwagandha and Purina uses a powder-based daily routine.
- The right pick depends on the stress pattern: a chew may suit an occasional routine, while a supplement intended for regular use calls for consistent administration and a check with your veterinarian.
| Calming Chews for Dogs, 180 Count |  | Best for Broad Ingredient Coverage | Count: 180 chews | Form: Soft chew | Flavor: Chicken-style | VIEW LATEST PRICE | See Our Full Breakdown |
| Pet Honesty Calming Chews for Dogs with Ashwagandha, Duck Flavor, 90 Count |  | Best Duck-Flavor Pick | Count: 90 chews | Flavor: Duck | Form: Soft chews | VIEW LATEST PRICE | See Our Full Breakdown |
| Greenies Calming Chews for Dogs, Chicken Flavor, 40 Count |  | Best for a Simpler Formula | Count: 40 | Flavor: Chicken | Form: Capsule, as listed in product specs | VIEW LATEST PRICE | See Our Full Breakdown |
| VetriScience Veterinary Strength Calm & Confident Chicken Chews for Dogs and Cats |  | Best for Multi-Pet Households | Brand: VetriScience | Count: 60 chews | Flavor: Chicken | VIEW LATEST PRICE | See Our Full Breakdown |
| Calming Chews for Dogs with Hemp, Melatonin, and Chicken Flavor |  | Best for a Straightforward Hemp Blend | Flavor: Chicken | Key ingredients: Hemp oil, valerian root, chamomile, melatonin | Formulation: Veterinarian formulated | VIEW LATEST PRICE | See Our Full Breakdown |
| Pet Naturals Calming Chews for Dogs and Cats, Chicken Flavor, 160 Count |  | Best for Multi-Pet Homes | Brand: Pet Naturals | Form: Soft chews | Quantity: 160 chews | VIEW LATEST PRICE | See Our Full Breakdown |
| NaturVet Quiet Moments Calming Plus Hemp Dog Supplement, 180 Soft Chews |  | Best for Travel and Storm-Day Routines | Brand: NaturVet | Form: Soft chews | Quantity: 180 soft chews | VIEW LATEST PRICE | See Our Full Breakdown |
| Hemp Calming Chews for Dogs – 240 Treats |  | Best for Large-Dog Households and Frequent Use | Form: Treats | Quantity: 240 treats | Flavor: Chicken | VIEW LATEST PRICE | See Our Full Breakdown |
| Pawzitive Pets Calming Chews for Dogs with Hemp, Melatonin, Chamomile, and Passion Flower, 120 Soft Treats |  | Best for Vet-Visit and Outing Prep | Form: Soft treats | Quantity: 120 soft treats | Key ingredients: Hemp seed oil, melatonin, chamomile, L-tryptophan, and passion flower | VIEW LATEST PRICE | See Our Full Breakdown |
| Purina Pro Plan Veterinary Supplements Calming Care Dog Supplement, 30 Count |  | Best Probiotic Powder Alternative | Brand: Purina Pro Plan Veterinary Supplements | Form: Powder | Quantity: 30 packets | VIEW LATEST PRICE | See Our Full Breakdown |
| Charlie & Buddy Hemp Oil for Dogs and Cats |  | Best Multi-Pet Oil | Form: Oil | Flavor: Natural | Active ingredients: Hemp seed oil extract, omega 3, 6, and 9 fatty acids, vitamins E and B | VIEW LATEST PRICE | See Our Full Breakdown |
| BARK&SPARK Hemp Calming Treats for Dogs |  | Best for Travel and Occasional Stress | Form: Soft chews | Key ingredients: Hemp and melatonin | Intended use: Support relaxation during stressful situations | VIEW LATEST PRICE | See Our Full Breakdown |
| Zesty Paws Calming Chews for Dogs, Peanut Butter, 90 Count |  | Best Broad-Ingredient Chew | Form: Chewables | Flavor: Peanut butter | Count: 90 | VIEW LATEST PRICE | See Our Full Breakdown |
| Native Pet Calming Chews for Dogs, Air-Dried, 30 Chews |  | Best for Daily or Event-Based Use | Form: Air-dried chews | Count: 30 chews | Active ingredients: Hemp seed, melatonin, L-theanine, casein | VIEW LATEST PRICE | See Our Full Breakdown |
| Rescue Remedy Pet Stress Support Drops for Dogs and Cats, 10 mL |  | Best Sedative-Free Drops for Dogs and Cats | Volume: 10 mL | Pet types: Dogs and cats | Form: Liquid drops | VIEW LATEST PRICE | See Our Full Breakdown |
| pet calming supplement | Form | Flavor | Key ingredients |
|---|---|---|---|
| Calming Chews for Dogs | Soft chew | Chicken-style | Ashwagandha, valerian root, chamomile, lemon balm, lavender, passion flower, L-theanine, L-tryptophan, GABA, melatonin |
| Pet Honesty Calming Chews for | Soft chews | Duck | — |
| Greenies Calming Chews for Dog | Capsule, as listed in product specs | Chicken | L-tryptophan and L-theanine |
| VetriScience Veterinary Streng | Chews | Chicken | L-theanine and thiamine |
| Calming Chews for Dogs with He | — | Chicken | Hemp oil, valerian root, chamomile, melatonin |
| Pet Naturals Calming Chews for | Soft chews | Chicken liver | — |
| NaturVet Quiet Moments Calming | Soft chews | — | Melatonin, ginger, L-tryptophan, and thiamin |
| Hemp Calming Chews for Dogs | Treats | Chicken | — |
| Pawzitive Pets Calming Chews f | Soft treats | — | Hemp seed oil, melatonin, chamomile, L-tryptophan, and passion flower |
| Purina Pro Plan Veterinary Sup | Powder | — | — |
| Charlie & Buddy Hemp Oil for D | Oil | Natural | — |
| BARK&SPARK Hemp Calming Treats | Soft chews | — | Hemp and melatonin |
| Zesty Paws Calming Chews for D | Chewables | Peanut butter | Suntheanine (L-theanine), ashwagandha, valerian root, organic hemp seed powder, organic passionflower, magnesium citrate, L-tryptophan, organic ginger root |
| Native Pet Calming Chews for D | Air-dried chews | Chicken | — |
| Rescue Remedy Pet Stress Suppo | Liquid drops | — | — |
More Details on Our Top Picks
Calming Chews for Dogs, 180 Count
I’d shortlist these for buyers who want a wide mix of calming ingredients in one everyday soft chew. Along with familiar options such as chamomile and valerian, the formula includes ashwagandha, L-theanine, L-tryptophan, GABA, and melatonin, giving it broader ingredient coverage than Greenies Calming Chews, which focuses on L-tryptophan and L-theanine. The 180-count supply and chicken-style flavor may suit households maintaining a regular routine, while the suggested timing of 30–60 minutes before stress offers a planning cue for travel or grooming. The tradeoff is that the provided information gives no dog-size dosage guidance or ingredient amounts, so I’d want clear label directions before choosing it for a specific pet. Its extensive blend may also be more than buyers seeking a simpler formula need.
Pros:- Broad blend includes botanicals, amino acids, GABA, and melatonin
- 180 soft chews provide a larger supply than Greenies Calming Chews
- Chicken-style flavor and soft texture may make routine administration easier
- GMP-compliant manufacturing and listed exclusions include corn, soy, wheat, and artificial preservatives
Cons:- No dosage guidance by dog size is provided
- Ingredient amounts are not specified in the supplied product information
- The multi-ingredient formula may not suit buyers who prefer a simpler ingredient profile
Best for: Dog owners seeking a large-count soft chew with a broad blend for both everyday routines and planned stressful events.
Not ideal for: Owners who need clearly stated dog-size dosing or ingredient amounts before selecting a supplement.
- Count:180 chews
- Form:Soft chew
- Flavor:Chicken-style
- Key ingredients:Ashwagandha, valerian root, chamomile, lemon balm, lavender, passion flower, L-theanine, L-tryptophan, GABA, melatonin
- Suggested timing:30–60 minutes before expected stress
- Manufacturing:GMP-compliant facility
- Free from:Corn, soy, wheat, nut derivatives, artificial preservatives, chemical flavorings
Our verdict“Choose this if you want a large supply and a broad ingredient blend, but check the label for dog-size dosing before buying.”
Pet Honesty Calming Chews for Dogs with Ashwagandha, Duck Flavor, 90 Count
Duck flavor gives this formula a distinct advantage for dogs less interested in chicken-style chews, while its ingredient list covers chamomile, valerian, L-theanine, ashwagandha, passion flower, and melatonin. The description presents it as non-sedating and suited to situations such as separation, travel, and loud noises, so it may appeal to owners looking for behavior support without a product positioned around drowsiness. Compared with the 180-count Calming Chews for Dogs, this 90-count option offers a smaller supply and a different flavor, but it also lists hemp seed powder and oil. The main drawback is practical: dosage instructions and ingredient amounts aren’t provided in the supplied details. I’d check the package directions before relying on it for a dog of a particular size.
Pros:- Duck flavor offers an alternative to the chicken flavors of Greenies and VetriScience
- Includes a broad selection of botanicals, amino acids, hemp ingredients, and melatonin
- Described as non-sedating
- Listed for dogs of all sizes and common stress situations such as travel and loud noises
Cons:- Dosage instructions are not specified in the supplied information
- Ingredient amounts are not listed
- 90 chews make for a smaller-count supply than the 180-count option in this roundup
Best for: Owners of dogs who prefer duck-flavored soft chews and want a multi-ingredient option for predictable stress triggers.
Not ideal for: Buyers who need published dog-size dosage directions or want a clearly stated ingredient-amount breakdown.
- Count:90 chews
- Flavor:Duck
- Form:Soft chews
- Active ingredients:Valerian root, chamomile, ginkgo biloba, hemp seed powder, hemp seed oil, passion flower, L-theanine, ashwagandha root, ginger root, lemon balm, L-tryptophan, magnesium citrate, melatonin
- Stated benefits:Behavior support and calming support
- Dog size:All sizes
- Item weight:9 ounces
Our verdict“Pick this for a duck-flavored, non-sedating-positioned chew, provided the package gives dosing directions that fit your dog.”
Greenies Calming Chews for Dogs, Chicken Flavor, 40 Count
I’d favor Greenies Calming Chews when a shorter ingredient list matters more than a large blend. The calming ingredients highlighted here are L-tryptophan and L-theanine, paired with real chicken and a formulation free of artificial flavors, colors, and fillers. That makes it a more focused alternative to Pet Honesty’s formula, which lists a much wider range of botanicals and other ingredients. Greenies may also suit buyers who value its stated formulation by animal nutritionists in the USA and its National Animal Supplement Council Quality Seal. The tradeoff is a 40-count supply, smaller than both Pet Honesty’s 90 chews and the 180-count broad-blend option. The supplied details also identify medium dogs but don’t provide dosage directions, so I’d check the package carefully before choosing it for a dog outside that size description.
Pros:- Focused calming ingredients include L-tryptophan and L-theanine
- Made with real chicken
- No artificial flavors, colors, or fillers
- Made in the USA and carries the National Animal Supplement Council Quality Seal
Cons:- 40-count supply is smaller than Pet Honesty’s 90 chews and the 180-count option
- Product details identify medium dogs rather than giving broad size guidance
- Dosage instructions and ingredient amounts are not included in the supplied information
Best for: Owners of medium-sized dogs who prefer chicken flavor, a focused ingredient list, and a product with a stated quality seal.
Not ideal for: Owners seeking a large-count supply, a broad botanical blend, or clear suitability details for dogs outside the medium-size category.
- Count:40
- Flavor:Chicken
- Form:Capsule, as listed in product specs
- Key ingredients:L-tryptophan and L-theanine
- Dog breed size:Medium
- Weight:7.3 ounces
- Allergen information:Corn-free, dairy-free, rawhide-free
- Quality and origin:Formulated by animal nutritionists; made in the USA; National Animal Supplement Council Quality Seal
Our verdict“Choose Greenies if you want a chicken-flavored chew with a focused formula for a medium-sized dog and don’t need a large supply.”
VetriScience Veterinary Strength Calm & Confident Chicken Chews for Dogs and Cats
One chew for dogs and cats is the main reason I’d rank this apart from the dog-only options in this roundup. VetriScience lists L-theanine and thiamine as its key ingredients and describes the chews as providing quick stress relief without drowsiness or personality changes. That is a more focused approach than the extensive botanical blends in Pet Honesty or the 180-count Calming Chews for Dogs, which may appeal to owners who don’t want as many listed actives. The 60-count bottle and chicken flavor give it a practical place in a multi-pet routine, but the supplied details don’t spell out dosage instructions or explain how serving directions differ between species. I’d verify those directions before sharing it between a dog and cat, and keep in mind that response can vary between individual pets.
Pros:- Listed for both dogs and cats, unlike the dog-only products in this batch
- Focused key ingredients are L-theanine and thiamine
- Described as supporting calm without drowsiness or personality changes
- Rawhide-free chicken-flavored chew
Cons:- Specific dosage instructions are not detailed in the supplied information
- Effectiveness may vary by individual pet
- The focused ingredient list may not suit buyers seeking a broader botanical blend
Best for: Households with both dogs and cats that want a chicken-flavored calming chew listed for both species.
Not ideal for: Owners who need detailed species-specific dosing in the product summary or want a wide botanical ingredient blend.
- Brand:VetriScience
- Count:60 chews
- Flavor:Chicken
- Form:Chews
- Target species:Dogs and cats
- Key ingredients:L-theanine and thiamine
- Item weight:7.2 ounces
- Allergen information:Rawhide-free
Our verdict“Choose VetriScience when you want one calming chew listed for both dogs and cats, and confirm species-specific directions before use.”
Calming Chews for Dogs with Hemp, Melatonin, and Chicken Flavor
This option keeps its headline blend comparatively straightforward: hemp oil, valerian root, chamomile, and melatonin. I’d consider it for owners who want those familiar ingredients without the longer lists found in Pet Honesty or the 180-count Calming Chews for Dogs. It is described as veterinarian formulated, made in the USA, and intended for dogs of all ages and sizes, with common triggers such as thunderstorms, travel, vet visits, and separation named in the product information. Those broad suitability claims make it sound flexible, but the supplied details leave out ingredient amounts and dosage directions. That makes it harder to compare serving plans or judge fit for a particular dog. Unlike VetriScience, it is presented for dogs only, so it won’t fill the same role in a household looking for a shared dog-and-cat option.
Pros:- Straightforward listed blend of hemp oil, valerian root, chamomile, and melatonin
- Described for common stress situations including travel and thunderstorms
- Veterinarian formulated
- Made in the USA and intended for dogs of all ages and sizes
Cons:- Ingredient amounts are not provided
- Dosage details are not supplied
- Dog-only suitability does not match VetriScience’s dog-and-cat positioning
Best for: Dog owners who want a chicken-flavored hemp-and-botanical chew described for dogs of all ages and sizes.
Not ideal for: Buyers who want published ingredient amounts, clear dosage instructions, or a product also listed for cats.
- Flavor:Chicken
- Key ingredients:Hemp oil, valerian root, chamomile, melatonin
- Formulation:Veterinarian formulated
- Country of manufacture:USA
- Suitable for:Dogs of all ages and sizes
- Named stress situations:Thunderstorms, travel, vet visits, separation
Our verdict“Consider this for a dog-only hemp-and-botanical blend, but choose another option if you need clear serving guidance before purchase.”
Pet Naturals Calming Chews for Dogs and Cats, Chicken Flavor, 160 Count
For homes with both dogs and cats, Pet Naturals is the clearest fit in this group: its soft chews are listed for both species and for pets of all sizes. The formula pairs colostrum, thiamine, and L-theanine, and the chews can be used routinely or for specific stressors such as travel, grooming, storms, or fireworks. That flexibility contrasts with NaturVet Quiet Moments, which is intended for dogs only and includes melatonin. The 160-count package also suits households that expect to use calming support regularly. The tradeoff is a chicken-liver flavor that may not appeal to every pet, and the description does not give serving guidance, so buyers should check the package directions and ask a veterinarian about fit for their animals.
Pros:- Listed for both dogs and cats of all sizes
- Can be used daily or as needed for stressful events
- Combines colostrum, thiamine, and L-theanine
- Large 160-chew package; contains no corn, wheat, or artificial flavors
Cons:- Chicken-liver flavor may not suit every pet
- Supplied information does not include serving instructions
Best for: Households with both dogs and cats that want one soft-chew calming supplement for routine use or occasional stressful events.
Not ideal for: Pets that refuse chicken-liver flavors, or owners who need a clearly specified serving plan before buying.
- Brand:Pet Naturals
- Form:Soft chews
- Quantity:160 chews
- Flavor:Chicken liver
- Suitable for:Dogs and cats of all sizes
- Active ingredients:Colostrum, thiamine (vitamin B1), and L-theanine
- Use:Daily or as needed for calming support
- Item weight:8.48 ounces
- Allergen information:Wheat free
Our verdict“Choose Pet Naturals if you want one flexible calming chew for dogs and cats and your pets accept chicken-liver flavor.”
NaturVet Quiet Moments Calming Plus Hemp Dog Supplement, 180 Soft Chews
NaturVet Quiet Moments is a dog-only choice for owners seeking a soft chew aimed at predictable stressors, including separation, storms, grooming, and travel. Its blend includes melatonin, ginger, L-tryptophan, and thiamin, giving it a different profile from Purina Pro Plan Calming Care, which uses a specified probiotic strain in powder packets rather than a chew. The 180-count resealable jar is practical for repeated use and helps keep the chews contained between outings. This is not the best match for mixed-species homes like those suited to Pet Naturals, since NaturVet is intended for dogs over 12 weeks. The supplied product details also omit dosage directions, so owners will need to follow the package label or consult their veterinarian rather than infer a serving.
Pros:- Targets common stressors including storms, travel, grooming, and separation
- Soft-chew format may be easier to give than a powder for dogs that accept treats
- Resealable jar helps keep the supply contained and fresh
- Made in the USA in a cGMP-compliant facility
Cons:- Intended for dogs over 12 weeks, not cats or younger puppies
- Supplied information does not include dosage instructions
- Includes melatonin, which may warrant veterinary guidance for some dogs
Best for: Dog owners who want a resealable supply of soft chews for recurring trips, storms, grooming appointments, or separation-related stress.
Not ideal for: Cat owners, dogs under 12 weeks, or buyers who want serving instructions clearly stated in the product details.
- Brand:NaturVet
- Form:Soft chews
- Quantity:180 soft chews
- Key ingredients:Melatonin, ginger, L-tryptophan, and thiamin
- Intended for:Dogs over 12 weeks
- Packaging:Resealable jar
- Made in:USA
Our verdict“Pick NaturVet for a dog-only soft chew in a resealable jar, provided you confirm the appropriate serving for your dog.”
Hemp Calming Chews for Dogs – 240 Treats
The 240-treat supply makes this a practical pick for owners expecting to give calming chews often, or for homes with more than one dog. Its formula brings together hemp, valerian root, chamomile, and melatonin for a mix of botanical ingredients and a sleep-associated ingredient. Compared with Pawzitive Pets Calming Chews, it offers a larger stated quantity, while both formulas combine hemp-related ingredients with melatonin and calming botanicals. The product is described as veterinarian-formulated and suitable for dogs of all sizes and ages, from puppies to seniors. That broad audience does not remove the need to check suitability: melatonin may not fit every dog’s health needs, and chicken flavor is a poor match for dogs with poultry allergies. The supplied details also do not specify servings per dog size.
Pros:- Large 240-treat quantity
- Combines hemp, valerian root, chamomile, and melatonin
- Described as veterinarian-formulated
- Listed for dogs of all sizes and ages
Cons:- Chicken flavor may not work for dogs with poultry allergies or food sensitivities
- Melatonin may not suit some dogs without veterinary advice
- Supplied information does not give serving instructions
Best for: Owners of multiple dogs or frequent users who want a large chicken-flavored supply and are comfortable checking the formula with a veterinarian.
Not ideal for: Dogs with poultry allergies, or dogs with health conditions for which melatonin requires veterinary review.
- Form:Treats
- Quantity:240 treats
- Flavor:Chicken
- Item weight:0.56 kg
- Target audience:Dogs of all sizes and ages
- Primary ingredients:Hemp, valerian root, chamomile, and melatonin
- Formulation:Veterinarian-formulated
- Origin:Made in USA
Our verdict“Choose this large-count option for frequent use across dogs, but check melatonin suitability and chicken ingredients first.”
Pawzitive Pets Calming Chews for Dogs with Hemp, Melatonin, Chamomile, and Passion Flower, 120 Soft Treats
Pawzitive Pets focuses on situational support, with the description naming travel, vet visits, fireworks, and separation as common use cases. Its veterinarian-developed formula combines hemp seed oil, melatonin, chamomile, L-tryptophan, and passion flower, a broader ingredient list than NaturVet Quiet Moments, which instead includes ginger and thiamin. The 120 soft treats offer a middle-sized supply: less than the 240-count Hemp Calming Chews, but more than a small trial-style pack would provide. That count does not tell buyers how long the supply lasts, because serving guidance is absent from the supplied details. Made in the USA is another stated point, but owners still need to verify the label and ask a veterinarian whether the melatonin-containing blend fits their dog.
Pros:- Designed around specific stressful events such as vet visits and travel
- Includes hemp seed oil, chamomile, L-tryptophan, and passion flower
- Veterinarian-developed formulation
- Made in the USA
Cons:- Supplied information does not include dosage or serving instructions
- Contains melatonin, which may require veterinary guidance for some dogs
- 120 treats may be a shorter supply than the 240-count alternative, depending on serving directions
Best for: Dog owners seeking a soft treat for occasional vet appointments, travel, fireworks, or separation-related situations.
Not ideal for: Owners who need explicit serving directions or want a supplement without melatonin.
- Form:Soft treats
- Quantity:120 soft treats
- Key ingredients:Hemp seed oil, melatonin, chamomile, L-tryptophan, and passion flower
- Formulation:Veterinarian-developed
- Made in:USA
- Intended use:Calming support for travel, vet visits, fireworks, or separation
Our verdict“Consider Pawzitive Pets for event-focused support when its multi-ingredient blend fits your dog and you can confirm the serving with a veterinarian.”
Purina Pro Plan Veterinary Supplements Calming Care Dog Supplement, 30 Count
Purina Pro Plan Calming Care stands apart from the chew-based picks: it is a powder supplement built around the named probiotic strain Bifidobacterium longum BL999, with a stated 1 × 10^9 CFU per packet. That specificity gives buyers a clearer view of the probiotic component than the ingredient lists for Pet Naturals Calming Chews, though Pet Naturals has the broader dog-and-cat fit and a soft-chew format. Calming Care is intended for dogs facing routine changes, unfamiliar visitors, separation, or new sounds, and the description also links it with positive cardiac activity during stressful events. The tradeoff is a 30-packet supply and a powder format that must suit the dog’s feeding routine. The supplied details do not include dosing directions, so check the package or ask a veterinarian before use.
Pros:- Uses the specified probiotic strain Bifidobacterium longum BL999
- States a probiotic count of 1 × 10^9 CFU per packet
- Powder format offers an alternative to flavored chews
- Aimed at everyday stressors such as new sounds, visitors, separation, and routine changes
Cons:- Dog-only product, unlike Pet Naturals’ dog-and-cat chews
- Powder may be less convenient for dogs that do not accept supplements with food
- Supplied information does not provide dosing instructions
- 30 packets offer a smaller stated supply than the multi-chew packages
Best for: Dog owners who prefer a measured probiotic powder and want a specified strain and CFU amount for routine stress support.
Not ideal for: Cat owners, dogs that will not accept powder with food, or buyers who need serving directions stated before purchase.
- Brand:Purina Pro Plan Veterinary Supplements
- Form:Powder
- Quantity:30 packets
- Probiotic:Bifidobacterium longum BL999
- Probiotic count:1 × 10^9 CFU per packet
- Intended use:Supports calm behavior during stressful events
- Named stressors:Separation, unfamiliar visitors, new sounds, and changes in routine
Our verdict“Choose Calming Care if a specified probiotic powder fits your dog’s feeding routine better than a chew-based calming supplement.”
Charlie & Buddy Hemp Oil for Dogs and Cats
Charlie & Buddy stands out for broad pet coverage: the hemp oil is formulated for both dogs and cats, and its listed uses extend beyond calming to include skin and coat, digestion, and joint support. Its omega 3, 6, and 9 fatty acids plus vitamins E and B give it a wider nutritional focus than BARK&SPARK Hemp Calming Treats, which are positioned around stressful moments with hemp and melatonin.
The tradeoff is a less clearly defined calming routine. The product information gives no dosage guide, and it does not provide ingredient amounts or detail supporting its broader relief claims. I’d choose it for a household that wants one oil for dogs and cats, but not for a buyer who needs precise directions or a narrowly specified calming formula.
Pros:- Formulated for dogs and cats of all breeds and sizes
- Oil form may suit pets that accept supplements mixed with food
- Includes omega 3, 6, and 9 fatty acids and vitamins E and B
- Lists calming, skin and coat, digestion, and joint support among its uses
Cons:- Product information does not provide a dosage guide
- Ingredient amounts are not specified
- Broader pain and seizure-relief claims lack supporting detail in the supplied information
Best for: Households with dogs and cats seeking a natural-form oil with calming support alongside skin, coat, and joint-health uses.
Not ideal for: Pet owners who need clear serving instructions or detailed evidence for specific pain or seizure-relief claims.
- Form:Oil
- Flavor:Natural
- Active ingredients:Hemp seed oil extract, omega 3, 6, and 9 fatty acids, vitamins E and B
- Item weight:2.88 ounces
- Pet suitability:Dogs and cats; small, medium, and all breeds
- Listed uses:Calming support, immune support, joint health, skin and coat health
- Allergen information:Codfish-free, dairy-free, gluten-free, soy-free
Our verdict“Choose Charlie & Buddy if you want a multi-use hemp oil for both cats and dogs and can confirm suitable dosing with your veterinarian.”
BARK&SPARK Hemp Calming Treats for Dogs
The travel-size soft chews give BARK&SPARK a clear niche for dog owners who want a portable option for storms, fireworks, or trips. Hemp and melatonin distinguish it from Charlie & Buddy Hemp Oil, which is a multi-use oil for dogs and cats rather than a dog-focused chew for stressful occasions. The soft, flavored format may also be easier to offer to dogs that resist pills.
The convenience comes with limited buying detail: no dosage or ingredient amounts are provided, so I can’t compare serving strength or judge how the formula fits a particular dog. Compared with Zesty Paws Calming Chews, BARK&SPARK is more explicitly travel-oriented, but Zesty Paws lists a broader set of calming-support ingredients. I’d favor this pick for portability, not for a fully specified daily supplement plan.
Pros:- Travel-size format is convenient to carry
- Soft chews may be easier to give than pills
- Combines hemp and melatonin
- Designed around recognizable stressful situations such as storms and fireworks
Cons:- No dosage guidance is provided
- Ingredient amounts are not disclosed
- Product details do not establish how the formula compares by strength with other calming chews
Best for: Dog owners who want a compact soft chew to take along for occasional triggers such as travel, fireworks, or storms.
Not ideal for: Owners who need ingredient quantities, dose guidance, or a clearly detailed formula before choosing a supplement.
- Form:Soft chews
- Key ingredients:Hemp and melatonin
- Intended use:Support relaxation during stressful situations
- Size:Travel-size
- Pet suitability:Dogs
- Examples of intended situations:Fireworks and storms
Our verdict“Pick BARK&SPARK for a portable, occasion-focused chew, but look elsewhere if dose and ingredient transparency are priorities.”
Zesty Paws Calming Chews for Dogs, Peanut Butter, 90 Count
Zesty Paws is the most ingredient-varied chew in this group, listing Suntheanine, ashwagandha, valerian root, passionflower, magnesium citrate, L-tryptophan, hemp seed powder, and ginger root. That gives buyers more named ingredients to compare than the two-ingredient hemp-and-melatonin approach in BARK&SPARK’s travel chews. Its peanut-butter flavor and 90-count format also suit owners looking for a regular chew supply rather than a small travel-focused option.
The stated target is normal stress, nervousness, and hyperactivity, not severe anxiety or a guaranteed response to a specific event. The product details also omit dosage and serving-size guidance, making it harder to match the count to a dog’s routine. I’d choose it when ingredient variety matters; Native Pet Calming Chews may be a better fit for someone who prefers a shorter listed active-ingredient set and a daily-or-event-use description.
Pros:- Lists a broad mix of calming-support ingredients, including Suntheanine and ashwagandha
- Chewable format is convenient for many dogs
- Peanut-butter flavor offers an alternative to chicken-flavored options
- 90-count package supports a longer supply than smaller-count options
Cons:- No dosage or serving-size details are provided
- Product description limits its stated use to normal stress, nervousness, and hyperactivity
- The long ingredient list does not include amounts in the supplied details
Best for: Dog owners seeking a chew with multiple named calming-support ingredients and a peanut-butter flavor.
Not ideal for: Owners looking for clear dosing directions or support claims aimed beyond normal stress and nervousness.
- Form:Chewables
- Flavor:Peanut butter
- Count:90
- Key ingredients:Suntheanine (L-theanine), ashwagandha, valerian root, organic hemp seed powder, organic passionflower, magnesium citrate, L-tryptophan, organic ginger root
- Intended use:Calming support for normal stress, nervousness, and hyperactivity in dogs
- Pet suitability:Dogs of all sizes
Our verdict“Choose Zesty Paws if a broad list of named ingredients matters more to you than transparent ingredient amounts or event-specific positioning.”
Native Pet Calming Chews for Dogs, Air-Dried, 30 Chews
Native Pet offers the clearest use pattern in this set: its air-dried chews are described for daily support or before events such as thunderstorms, fireworks, travel, and vet visits. The formula lists hemp seed, melatonin, L-theanine, and casein, and specifies that its hemp is non-psychoactive seed, not CBD, and THC-free. That detail sets it apart from Charlie & Buddy Hemp Oil, whose supplied description does not make the same hemp distinction.
The tradeoff is a smaller 30-chew count and the possibility that ongoing support may call for consistent daily use. The product information advises veterinary consultation for puppies and dogs taking medication, which narrows its fit for some households. Compared with Zesty Paws’ longer ingredient list, Native Pet is easier to parse, but it offers fewer listed active ingredients and does not suit buyers who want a large-count supply.
Pros:- Described for daily use or before specific stressful events
- Specifies that the hemp is seed-based, non-psychoactive, not CBD, and THC-free
- Air-dried chicken-flavored chew format
- Made in the USA and carries the NASC Quality Seal
Cons:- 30 chews may be a limited supply for ongoing use
- Ongoing support may require consistent daily use
- Veterinary consultation is advised for puppies and dogs taking medication
Best for: Dog owners who want a clearly described chew for either regular routines or predictable events such as travel and vet visits.
Not ideal for: Owners seeking a larger-count supply, or those choosing supplements for puppies or medicated dogs without first consulting a veterinarian.
- Form:Air-dried chews
- Count:30 chews
- Active ingredients:Hemp seed, melatonin, L-theanine, casein
- Hemp details:Non-psychoactive hemp seed; not CBD; THC-free
- Flavor:Chicken
- Manufacturing:Made in the USA
- Certification:NASC Quality Seal
- Intended use:Daily support or use before stressful situations
Our verdict“Choose Native Pet for a straightforward daily-or-event-use chew with clearly identified hemp, provided its smaller count fits your routine.”
Rescue Remedy Pet Stress Support Drops for Dogs and Cats, 10 mL
Rescue Remedy is the lineup’s distinct liquid option, made for both dogs and cats and usable by mouth or mixed into food, water, or a treat. That flexibility contrasts with Native Pet Calming Chews, which are dog-only and require a chew format. Its sedative-free, vegan, and non-alcohol attributes may appeal to households that prefer drops and want to avoid adding a chew to a pet’s routine.
The key tradeoff is the evidence basis: the claims rely on traditional homeopathic practices, not accepted medical or scientific evidence, and the product is not evaluated by the FDA. I would not treat it as equivalent to supplements with specified ingredients such as Zesty Paws’ L-theanine and ashwagandha. This is a fit for buyers who specifically want flower-essence drops and accept that limitation, rather than those seeking a clearly substantiated calming formula.
Pros:- Can be given by mouth or mixed into food, water, or a treat
- Suitable for dogs and cats
- Sedative-free liquid format
- Vegan, vegetarian, non-alcohol, and free of listed common grains and soy
Cons:- Effectiveness claims rely on traditional homeopathic practices, not accepted medical or scientific evidence
- Not evaluated by the FDA
- The supplied product details do not give ingredient amounts
Best for: Multi-pet households seeking sedative-free drops that can be given directly or mixed into food, water, or a treat.
Not ideal for: Owners who want calming claims supported by accepted medical or scientific evidence or who prefer supplements with clearly specified active ingredients and amounts.
- Volume:10 mL
- Pet types:Dogs and cats
- Form:Liquid drops
- Active ingredients:Bach natural flower essences
- Sedative-free:Yes
- Dietary attributes:Vegan, vegetarian, non-alcohol; no grain, wheat, corn, or soy
- Origin:Made in the UK
- Administration:By mouth or mixed into food, water, or a treat
Our verdict“Choose Rescue Remedy only if you specifically want flexible, sedative-free flower-essence drops and accept the stated evidence limitations.”
How We Picked
I compared these 15 products by the factors that shape a real purchase: species labeling, delivery format, ingredient information presented in the product name, serving practicality, and how easily the product could fit a repeatable routine. I also looked at the range of choices represented here, from multi-ingredient soft chews to powder, oil, and drops. I did not treat a long ingredient list, large count, or a particular ingredient as proof that a supplement will work for every animal.
The ranking favors options with a clearly defined use case and a format likely to suit the buyer described. VetriScience ranks first for its stated dog-and-cat use and straightforward chew format; Pet Naturals and Purina stand out for different routine needs, rather than being interchangeable picks. Chews with narrower species labeling, less detail in the supplied product name, or a more specialized format rank lower for general use, though they may fit a particular household better. Since individual response and product directions matter, I recommend checking the full label and consulting a veterinarian when symptoms are severe, persistent, or new.
| pet calming supplement | Flavor |
|---|---|
| Calming Chews for Dogs | Chicken-style |
| Pet Honesty Calming Chews for | Duck |
| Greenies Calming Chews for Dog | Chicken |
| VetriScience Veterinary Streng | Chicken |
| Calming Chews for Dogs with He | Chicken |
| Pet Naturals Calming Chews for | Chicken liver |
| NaturVet Quiet Moments Calming | — |
| Hemp Calming Chews for Dogs | Chicken |
| Pawzitive Pets Calming Chews f | — |
| Purina Pro Plan Veterinary Sup | — |
| Charlie & Buddy Hemp Oil for D | Natural |
| BARK&SPARK Hemp Calming Treats | — |
| Zesty Paws Calming Chews for D | Peanut butter |
| Native Pet Calming Chews for D | Chicken |
| Rescue Remedy Pet Stress Suppo | — |
Factors to Consider When Choosing Best Pet Calming Supplements
I’d choose a calming supplement by starting with the situation it needs to fit, then checking species, format, and the label’s directions. The product name can signal ingredients or delivery style, but it cannot tell you whether a formula is suitable for your pet’s health, age, or other supplements. These checks help avoid buying a product that sounds right but proves difficult to give consistently.
Match the supplement to the reason for use
First identify when the behavior occurs: around travel, visitors, grooming, separation, or as part of a recurring routine. A supplement marketed for calming is not a universal answer to every behavior, and stress can also be linked to pain or illness. Keep a short log of the trigger, timing, and behavior so you can describe the pattern to your veterinarian. Avoid choosing a product just because its name mentions a familiar stress trigger; check the actual directions and intended use. If behavior is sudden, intense, or worsening, seek veterinary guidance before relying on an over-the-counter product. The best fit is the one that suits the situation and can be used as directed.
Check species, health, and the full ingredient label
Do not assume a dog supplement is suitable for a cat, even when both animals live in the same home. This lineup includes a few products labeled for both dogs and cats, but most are presented as dog products. Read the complete ingredient panel, serving directions, cautions, and age guidance rather than relying on the front label. If your pet takes medication, has a health condition, is pregnant, or is very young or old, ask a veterinarian about compatibility. A familiar ingredient name does not establish that the complete formula is appropriate for your animal. This step matters more than selecting a product based on a trend or a high ingredient count.
Choose a format your pet will reliably take
Soft chews are convenient when a pet accepts treats, but texture, flavor, and size can put off a picky eater. Powders may mix into food, yet they only work as a practical choice if your pet finishes the meal and you can repeat the routine. Oils and drops can suit animals that reject chews, though they require careful measuring and a method your pet tolerates. Avoid switching formats without checking whether the product directions allow it or how serving amounts differ. A supplement that stays in the cupboard because administration is difficult offers little practical value. Think about your pet’s eating habits before weighing ingredient claims.
Plan around frequency, timing, and consistency
Products in this roundup include chews and powders with different suggested routines, so do not assume every calming supplement is used the same way. Read whether the label describes regular use, use around a particular event, or another schedule, and follow those directions rather than improvising. Some routines may require advance planning; a product name alone does not show when to start or how soon to expect a response. Avoid giving extra servings because a stressful moment continues, and check with a veterinarian before combining calming products. A written routine makes it easier to notice whether anything changes and to share accurate details at a veterinary visit. If the label leaves timing unclear, ask the manufacturer or your veterinarian before use.
Compare supply size with the serving directions
A high count does not automatically make a product the better value: the number of servings depends on the directions for your pet’s size and the frequency of use. Compare the labeled serving amount, container quantity, and how often you expect to use the product before choosing a larger pack. A smaller container can make sense when you are checking whether your pet accepts a flavor or format, while a larger supply may suit an established routine. Also check storage instructions and any guidance on use after opening. Do not buy a bulk supply before confirming your pet can take the product and that it fits their needs. This comparison is more useful than judging a container by count alone.
Know when a supplement is not enough
Calming supplements are not substitutes for veterinary care, behavior support, or changes to an environment that is causing distress. If your pet panics, risks injury, stops eating, or shows a sudden behavior shift, contact a veterinarian instead of trying a succession of products. For ongoing issues, ask whether a behavior plan or specialist referral would help alongside any supplement. Keep expectations measured: product labels describe intended use, not a guaranteed outcome for every animal. Avoid stacking multiple formulas without professional advice, particularly when their ingredients overlap. Choosing a supplement responsibly includes knowing when the problem calls for a different kind of help.
Frequently Asked Questions
Can I give a dog calming supplement to my cat?
Only use a product if its label specifically includes cats and its directions cover your cat’s size and situation. In this lineup, VetriScience Calm & Confident and Pet Naturals are presented for dogs and cats, while many of the other options are labeled for dogs. Do not infer cat safety from a shared ingredient or from a pet-friendly product name. Cats can differ from dogs in how they respond to ingredients, and small serving errors can matter. Ask your veterinarian before giving a dog-only product or adapting a dog serving for a cat.
Should I choose a chew, powder, oil, or drops?
Choose the format your pet will take consistently and that you can administer according to its label. Chews may be convenient for treat-motivated pets, while a powder can fit a meal routine if your pet reliably eats the whole portion. Oil or drops can help when chews are refused, but measuring and administration may take more effort. The lineup’s different formats are not interchangeable, so check serving directions rather than transferring a routine from one product to another. If your pet refuses a format or only eats part of a dose, ask your veterinarian about a more workable option.
Can I combine two calming supplements?
Do not combine products without checking with your veterinarian. Two formulas may share ingredients even when their names emphasize different components, and combining them can make it hard to track what your pet receives or how they respond. This matters especially when products include multiple herbs or melatonin, or when your pet already takes medication. Bring the labels or ingredient panels to the conversation so your veterinarian can review the full formulas. Follow each product’s directions and avoid adding extra servings to compensate for an unclear result.
How do I compare a large-count chew with a smaller pack?
Compare the number of labeled servings rather than the number of pieces alone. Serving amounts may vary by pet size, and a product used regularly will be consumed differently from one reserved for occasional situations. Check how often the directions call for use, whether your pet accepts the flavor, and how the container should be stored after opening. A smaller pack can be a sensible first choice when you are unsure about acceptance or fit. Once a routine suits your pet, you can judge supply needs from the label instead of assuming that the largest count is the best choice.
When should I contact a veterinarian instead of trying another supplement?
Contact a veterinarian if the behavior is sudden, severe, getting worse, or affecting eating, sleep, safety, or daily life. Stress-like behavior can have a medical cause, so changing supplements repeatedly may delay useful care. Ask for guidance before giving a product to a pet with a health condition, one taking medication, or one whose age makes label directions unclear. A veterinarian can also help decide whether environmental changes or behavior support belong in the plan. If your pet has a strong reaction after taking a supplement, stop giving it and seek veterinary advice.
Conclusion
For a broadly useful first choice, I’d start with VetriScience Calm & Confident, particularly when a household needs a chew labeled for both dogs and cats. For best value by routine flexibility, compare the serving directions on Pet Naturals against your pet’s needs rather than choosing by container count; it also carries dog-and-cat labeling. Best for beginners is a simple format your pet already accepts: a chew for a treat-friendly dog, or a clearly labeled powder such as Purina Pro Plan Calming Care if adding a supplement to food fits your routine. For a premium-style daily powder option, Purina is the distinct choice in this lineup, while buyers seeking a liquid should compare Rescue Remedy with Charlie & Buddy Hemp Oil and check directions and species suitability. For specific needs, choose by the label and format: Pet Honesty highlights ashwagandha, several chews feature hemp or herbal blends, and the liquid products suit buyers who want an alternative to treats. If the behavior is persistent or severe, ask a veterinarian before relying on a supplement.
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